METHOD AND COMPOSITIONS FOR EVALUATING RISK OF DEVELOPING TYPE 2 DIABETES IN PEOPLE OF CHINESE DESCENT

摘要

Methods and compositions for identifying mutations and polymorphisms in mutant genes encoding gene product involved in insulin secretion, for example, hepatocyte nuclear factor-1 PROPORTIONAL , glucokinase, amylin and mitochondrial DNA are disclosed. Specifically, a microchip comprising a combination of at least two different mutant genes wherein each gene comprises at least one mutation indicative of a predisposition for type-2 diabetes in a member of a Chinese population is disclosed. A kit comprising the microchip, an isolated nucleic acid, primers and probes which are specifically used to screen or identify the mutations in genes of hepatocyte nuclear factor-1 PROPORTIONAL , glucokinase, amylin and mitochondrial DNA are also disclosed.