| 发明名称 |
ENZYME-ACTIVATED CYTOSTATIC CONJUGATES WITH INTEGRIN LIGANDS |
| 摘要 |
<p>The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to <v?3 integrin antagonists via preferred linking units which can be selevtively cleaved by elastase, i.e. by an enzyme which can especially be found in tumour tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and ?v?3 integrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.</p> |
| 申请公布号 |
WO02072151(A1) |
申请公布日期 |
2002.09.19 |
| 申请号 |
WO2002EP02501 |
申请日期 |
2002.03.07 |
| 申请人 |
BAYER AKTIENGESELLSCHAFT;LERCHEN, HANS-GEORG;BAUMGARTEN, JOERG;SCHOOP, ANDREAS;ALBERS, MARKUS |
发明人 |
LERCHEN, HANS-GEORG;BAUMGARTEN, JOERG;SCHOOP, ANDREAS;ALBERS, MARKUS |
| 分类号 |
A61K47/16;A61K31/4375;A61K31/4709;A61K38/00;A61K47/22;A61K47/48;A61P35/00;A61P43/00;C07K5/08;C07K5/10;(IPC1-7):A61K47/48 |
主分类号 |
A61K47/16 |
| 代理机构 |
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