INHALER WITH MEANS FOR IMPROVING CHEMICAL STABILITY OF MEDICINAL AEROSOL SOLUTION CONTAINED THEREIN

摘要

The present invention relates to a medicinal aerosol solution formulation product with improed chemical stability, comprising a pressurized metered do se inhaler (10), comprising an aerosol canister (16) equipped with a metering valve (18) and containing a medicinal aerosol solution formulation (12) containing an active ingredient subject to a degradation by means of peroxid es or other leachables, a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component, wherein optionally part or all of the internal surfaces of said inhaler consists of stainless steel, anodized aluminum or are lined with an inert organic coating, and wherein the caniste r has a rim with rounded edges which avoids contact of a sharp edge with the rubbers used as valve gaskets.