| 发明名称 |
Caspase inhibitors and uses thereof |
| 摘要 |
This invention provides novel compounds that are effective as inhibitors of caspase and cellular apoptosis. The invention also provides methods for using the compounds to treat caspase-mediated diseases in mammals. The compounds have the general formula I: wherein X is F or Cl; R1 is COOH, COO(alkyl), or an isostere thereof; and R2 is an aryl group.
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| 申请公布号 |
US2002132833(A1) |
申请公布日期 |
2002.09.19 |
| 申请号 |
US20010834052 |
申请日期 |
2001.04.03 |
| 申请人 |
GOLEC JULIAN M.C.;CHARIFSON PAUL;BRENCHLEY GUY |
发明人 |
GOLEC JULIAN M.C.;CHARIFSON PAUL;BRENCHLEY GUY |
| 分类号 |
A61K31/197;A61K31/275;A61K31/341;A61K31/381;A61K31/40;A61K31/404;A61K31/426;A61K31/4409;A61K31/455;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P5/16;A61P7/04;A61P7/06;A61P9/04;A61P9/10;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P17/14;A61P21/00;A61P21/02;A61P21/04;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P29/00;A61P31/00;A61P31/06;A61P31/12;A61P31/18;A61P31/20;A61P33/02;A61P35/00;A61P35/02;A61P37/00;A61P37/06;A61P43/00;C07C231/12;C07C233/83;C07C235/52;C07C237/36;C07C253/30;C07C255/57;C07C255/60;C07D207/34;C07D207/416;C07D209/42;C07D213/81;C07D213/82;C07D277/20;C07D277/56;C07D307/68;C07D333/38;C07D333/40;(IPC1-7):A61K31/455;A61K31/401;A61K31/195;C07D333/22;C07D213/56 |
主分类号 |
A61K31/197 |
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