| 摘要 |
The present invention relates to a remedy for diseases caused by insulin resistance, which comprises, as an active ingredient, a substance exhibiting activity for inhibiting the binding of the full-length insulin receptor substrate-1 (IRS-1) or insulin receptor substrate-2 (IRS-2) or a portion of the same to the full-length 14-3-3 protein or a portion of the same; and to a screening method for a remedy for diseases caused by insulin resistance, which comprises assaying the activity for inhibiting the binding. By means of the screening method, there can be obtained a remedy for diseases caused by insulin resistance, such as diabetes, diabetic microangiopathies (diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy), impaired glucose tolerance, hyperinsulinemia, hyperlipemia, arteriosclerosis, hypertension, obesity, ischemic heart diseases, ischemic brain disorders, and peripheral arterial embolism.
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