| 摘要 |
<p>An electroporation system comprises a forcep device (20) in which a support member (22) supports a pair of electrodes (24,26), connected by insulated linkage, at its distal end. A piston grip handle (28), disposed at the proximal end of the support member (22), incorporates a movable handle (30) by means of which the distance between the electrodes (24, 26) may be adjusted. The electrodes are connected to a pulse generator (36) via a connecting cable (34), and a sensing unit (38) senses the gap between electrodes (24,26), transmitting a signal to the pulse generator via conductor cable (40). With a selected tissue gripped between the electrode jaws, an electrical field of predetermination amplitude and generation is repeatedly applied to the tissue, making cell walls transiently permeable to admit macromolecules introduced by syringe or other means. The unit may be inserted into a cavity of a patient by minimally invasive surgery, using a tube (12). Also claimed is an alternative embodiment comprising a pair of spaced apart arrays of conductive needle electrodes (46,48) adjustably disposed to span the treatment site. The distance between arrays may be determined by various means, and fed manually or automatically into the pulse generator.</p> |
