Haloaccloacetate reductase, method for producing said enzyme, and method for producing alcohols using said enzyme

摘要

A novel enzyme is provided. This enzyme is capable of reducing 4-haloacetoacetic acid esters to produce (S)-4-halo-3-hydroxybutyric acid esters with high optical purity. The enzyme was isolated from a microorganism belonging to the genus Kluyveromyces. Using the enzyme, (S)-4-halo-3-hydroxybutyric acid esters, which are useful as HMG-CoA reductase inhibitors, intermediates for synthesizing various medicines and agricultural chemicals, can be efficiently produced with high optical purity.