| 摘要 |
PURPOSE: A manufacturing method of microcapsules having superior biocompatibility and high manufacturing efficiency is provided. CONSTITUTION: The manufacturing method of microcapsules comprises the steps of preparing a solution in which surfactant is added to a biocompatibility natural polymer solution or natural polymer solution; and manufacturing microcapsules by homogenizing the materials after adding a core material, a coagulant (a wall forming agent), and a solution in which surfactant is dissolved in an organic solvent in certain cases to the surfactant added solution, wherein the biocompatibility capsules are protein such as sodium alginate, chitosan, gelatin, keratin, lipoprotein and fibrin, the core material comprises oil, dyestuff, pigment, incense, foodstuffs, medication, agricultural chemicals, adhesive, lipophilic cosmetics, or skin activating constituents, sodium alginate and chitosan are preferably used as a capsule material, 1 to 8 wt.% of ESPR-25 (polyglycerin polylinoleate, HLB=0.5), ES-7 (glycerin monostearate, HLB=3.8-4.3), SPAN-60 (sorbitan stearate, HLB=6.8-8.6), SE-11 (sucrose fatty acid ester, HLB=11), MP-8, TW-80, TW-20(sorbitan laurate + ethylene oxide, HLB=16) or a mixture thereof depending on HLB values is used as an emulsifier for the total amount of the solution, and a solution of the capsule material is controlled to 0.1 to 5.0 wt.%, and more preferably to 1 to 3 wt.%.
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