发明名称 |
Process for producing optically active threo-3-amino-1,2-epoxy compounds |
摘要 |
Highly pure optically active threo-3-amino-1,2-epoxy compounds appropriate for materials for manufacturing drugs and a process for producing the same on an industrial scale. An optically active threo-3-amino-1,2-diol derivative is subjected in an organic solvent in the presence of a base to alkylsufonylation or arylsulfonylation to thereby give the corresponding optically active threo-3-amino-2-hydroxy-1-sulfonyloxy compound. Next, the resultant product is subjected to epoxidation in the presence of a base to give the corresponding optically active threo-3-amino-1,2-epoxy compound. The thus obtained epoxy compound is purified by using an organic solvent and water, thus giving a highly pure epoxy compound.
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申请公布号 |
US6452026(B1) |
申请公布日期 |
2002.09.17 |
申请号 |
US20010997875 |
申请日期 |
2001.11.30 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
SAGAWA YUKIHIRO;SEKINE JOUJI;SATO HISAO |
分类号 |
C07C303/28;C07C309/66;C07D303/36;(IPC1-7):C07D301/02 |
主分类号 |
C07C303/28 |
代理机构 |
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地址 |
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