发明名称 |
Small molecules that elicit a polarized Th1 response and for modulation of cellular immunity |
摘要 |
The present invention relates to methods of using peptide-like compounds, e.g., aminocarboxylic acid amide derivatives, to bias the immune system toward producing, enhancing, or maintaining a polarized Th1 response, and to methods for treating diseases that improve by creating a Th1 response. The invention also relates to a method of treating diseases associated with elevated soluble TNF alpha levels by administering beta-alethine together with NAC to reduce soluble TNF alpha, and to a pharmaceutical composition comprising same. The present compounds can be used to modulate cytokines including IFN-gamma and IL-10.
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申请公布号 |
US6451853(B1) |
申请公布日期 |
2002.09.17 |
申请号 |
US19990256762 |
申请日期 |
1999.02.24 |
申请人 |
DOVETAIL TECHNOLOGIES, INC |
发明人 |
TAUB FLOYD E.;PONTZER CAROL H. |
分类号 |
A61K38/00;A23L1/30;A61K31/00;A61K31/16;A61K31/195;A61K31/215;A61K31/275;A61K31/66;A61K31/675;A61K45/06;A61P39/06;A61P43/00;C07C323/41;C07K5/00;C07K5/06;C07K5/08;(IPC1-7):A61K31/275 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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