Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines

摘要

Treatment of endotoxic shock in a mammal comprises administering, in a vehicle, an agent (I) that inhibits production of tumor necrosis factor (TNF) or interleukin-6 (IL-6). ACTIVITY : Antiinflammatory; antibacterial; immunosuppressive. MECHANISM OF ACTION : Inhibiting production of pro-inflammatory cytokines. Murine peritoneal macrophages were stimulated with lipopolysaccharide (LPS; 10 ng/ml) in presence of 0.001 mu M vasoactive intestinal peptide (VIP). The production of IL-6 was about 800 ng/ml in absence of VIP but only about 160 ng/ml in its presence. Production of TNF by the same cells was also suppressed, e.g. the maximum level was reduced from about 1400 pg/ml to about 600 pg/ml.