发明名称 |
PROCEDIMIENTO PARA LA PREPARACION DE LOS ENANTIOMEROS DEL 1-(4-CLOROFENIL)-2-CLOROETANOL. |
摘要 |
Prodn. of enantiomers of 1-(4-chlorophenyl)-2-chloroethanol (I) comprises:(a) hydrolysing racemic ( plus or minus )- alpha -(4-chlorophenyl)chloroethyl acetate (II) with a lipase prepn.;(b) sepg. the resulting S(+)-1-(4-chlorophenyl)-2-chloroethanol (Ia) from the unhydrolysed R(-)- alpha -(4-chlorophenyl)chloroethyl acetate (IIa), opt. after converting (Ia) to its succinate (Ib), and(c) hydrolysing (IIa) and opt. (Ib). The lipase prepn. is equine liver acetone extract powder, Pseudomonas fluorescens lipase PS, Pseudomonas lipase AK or Candida antarctica lipase. Also claimed are (Ia) and (IIa) prepd. as above.
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申请公布号 |
ES2171516(T3) |
申请公布日期 |
2002.09.16 |
申请号 |
ES19950402839T |
申请日期 |
1995.12.18 |
申请人 |
SANOFI-SYNTHELABO |
发明人 |
ZARD, LYDIA;TIXIDRE, ARLETTE |
分类号 |
C07C29/09;C07C31/36;C07C69/63;C07D211/18;C12P7/22;C12P41/00;C12R1/38;C12R1/39;C12R1/72;(IPC1-7):C12P41/00;C07B57/00;C07C69/40 |
主分类号 |
C07C29/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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