| 摘要 |
Seco-baccatin III derivatives of formula: wherein R, R<SUB>1</SUB>-R<SUB>4</SUB>, <?delete-start id="DEL-S-00001" date="20070710" ?>R<SUP>1</SUP><?delete-end id="DEL-S-00001" ?> <?insert-start id="INS-S-00001" date="20070710" ?>R'<?insert-end id="INS-S-00001" ?>, <?delete-start id="DEL-S-00002" date="20070710" ?>R<SUP>11</SUP><?delete-end id="DEL-S-00002" ?> <?insert-start id="INS-S-00002" date="20070710" ?>R''<?insert-end id="INS-S-00002" ?>, and <?delete-start id="DEL-S-00003" date="20070710" ?>R<SUP>111</SUP><?delete-end id="DEL-S-00003" ?> <?insert-start id="INS-S-00003" date="20070710" ?>R'''<?insert-end id="INS-S-00003" ?> are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administrating to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed. |
