| 摘要 |
The invention relates to highly pure, crystalline, stable compounds of 3,3-diphenylpropylamyie derivatives, in the form of their salts, a method for their production and highly pure, stable, intermediate products. The method is particularly characterized by regio- and chemo-selectivity and high yields and provides salts of phenolic monoesters of 3,3-diphenylpropylamines, which are particularly suitable for application in technical pharmaceutic formulations. Preferred compounds are R-(+)-2-(3-diisopropylammo-l-phenylpropyl)-4-hydroxyinethylphenyl isobutyrate hydrogenfurnarate and R-(+)-2-(3-diisopropylainino-l-phenylpropyi)-4-hydxymethylphenyl isobutyrate hydrochlodde hydrate. The method further provides essential, stable, crystalline intermediate products for the production of the above salts. A preferred intermediate product is R-(-)-3-(3-diisopropylaniinophenylpropyl)-4-hydroxybenzoic add methyl ester. |
