| 摘要 |
The present invention provides a method for identifying a subject having a risk of developing obesity, coronary microvascular dysfunction, or hypertension, comprising detection of the presence of a single nucleotide polymorphism (SNP) in a nucleic acid encoding an element of at least one beta -adrenergic receptor from the subject. The presence of the SNP is correlated with obesity, coronary microvascular dysfunction, or hypertension, and thereby identifies the subject as having a risk of developing obesity, coronary microvascular dysfunction, or hypertension. The subject invention also provides methods of identifying patients likely to benefit from the prescription of beta blocker hypertension medications. In varioius embodiments, the nucleic acids detected include those genes encoding ADRB1 ( beta 1AR), ADRB2 ( beta 2AR), ADRB3 ( beta 3AR), GNB3 (G protein beta 3 subunit), or GNAS1 (Gs protein alpha subunit). Methods of treating identified individuals are also provided. |
