发明名称 |
PROCESS FOR THE PREPARATION OF 1,2-BENZISOXAZOLE-3-ACETIC ACID |
摘要 |
The present invention provides a process for preparing 1,2-benzisoxazole-3-acetic acid, comprising the step of reacting 4-hydroxy-coumarin with hydroxyl-amine in the presence of a base. The present invention further provides a process for preparing a salt of benzisoxazole methane sulfonic acid, comprising the steps of 1) sulfonating 1,2-benzisoxazole-3-acetic acid using chlorosulfonic acid in a solvent mixture comprising methylene chloride and sodium hydroxide; and 2) isolating the salt of benzisoxazole methane sulfonic acid.
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申请公布号 |
WO02070495(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
WO2002US06419 |
申请日期 |
2002.03.04 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;MENDELOVICI, MARIORARA;NIDAM, TAMAR |
发明人 |
MENDELOVICI, MARIORARA;NIDAM, TAMAR |
分类号 |
C07D261/20;(IPC1-7):C07D261/18 |
主分类号 |
C07D261/20 |
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