Maturation of dendritic cells by recombinant heat shock protein 70

摘要

This invention is directed to ex vivo and in vivo methods for inducing the TNF-alpha free differentiation of immature dendritic cells into mature dendritic cells as well as methods for generating said mature dendritic cells. The invention is further directed to mature dendritic cells obtainable by said methods. Furthermore, the invention is directed to therapeutic compositions comprising an effective amount of heat shock proteins of the hsp70 family or of said mature dendritic cells as well as their use in the immunotherapy of neoplastic diseases. Finally, the present invention is directed to an immunotherapy for treating neoplastic diseases in an animal.