| 摘要 |
The invention provides isolated nucleic acid molecules, designated ABCG4 transporter nucleic acid molecules, which encode novel ABC transporter famil y members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCG4 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced , and non-human transgenic animals in which an ABCG4 transporter gene has been introduced or disrupted. The invention further provides isolated ABCG4 transporter proteins, fusion proteins, antigenic peptides, anti-ABCG4 transporter antibodies, and screening assays for ABCG4 transporter modulator s. Diagnostic and therapeutic methods utilizing compositions of the invention a re also provided.
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