Therapeutical method involving subcutaneous administration of drugs containing cephalotaxine derivatives

摘要

A new method of therapy using the subcutaneous mode of administration of formulations based upon harringtonines including their salts and tautomeric forms having the formula where: R1 is H, OH, OMe, O-(C1-C30)alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30-cycloalkyl or null and R2 is H or OH, or R1, R2 form together -O-. R3 =R4 50 OMe or R3 and R4 form together -OCH2O-, n is 0 to 8, R5 is H, OH, OMe, O-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or O-aryl, Z=O, S, or NH, and or Z-R8 is NR12R13, R12 and R13 representing respectively R9 and R10, R9, R10, R11 are independently H, C1-C30 alkyl, C3C30 cycloalkyl, aryl, aryl-(C1-C30)-alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C1-C30trihalogenoalkyl, C1-C30alkylamino-(C1-C30)alkyl, C1-C30 dialkylamino(C1-C30)-alkyl, or amino-(C1-C3)-alkyl, or where R14, R15, R16 are independently H, halogen, C1-C30 alkyl, C3