METHODS OF IDENTIFYING AGENTS AFFECTING ATROPHY AND HYPERTROPHY

摘要

The present invention provides a method for inhibiting atrophy or causing hypertrophy in muscle cells, by inhibiting the action of the phosphatase SHIP2. It further provides a method for inhibiting skeletal muscle atrophy or causing skeletal muscle hypertrophy in vertebrate animals, by inhibiting the Akt pathway through the inhibition of SHIP2. It also provides a method of identifying agents that may be used for inhibiting atrophy or causing hypertrophy in muscle cells, by screening for inhibitors of SHIP2 or inhibitors of the SHIP2 signaling pathway.