POROUS BETA-TRICALCIUM PHOSPHATE GRANULES AND METHODS FOR PRODUCING SAME

摘要

A porous beta -tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 µm, preferably 50-125 µm. The porous beta -TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous beta -TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous beta -TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous beta -TCP material and including bone formation are also provided.