A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.
申请公布号
WO0184921(A3)
申请公布日期
2002.09.12
申请号
WO2001US13162
申请日期
2001.04.24
申请人
WYETH;YOUNG, KATHLEEN;HOWLAND, DAVID, S.;MARQUIS, KAREN, L.;ROSENZWEIG-LIPSON, SHARON;COCKETT, MARK, IAN
发明人
YOUNG, KATHLEEN;HOWLAND, DAVID, S.;MARQUIS, KAREN, L.;ROSENZWEIG-LIPSON, SHARON;COCKETT, MARK, IAN