发明名称 |
MODIFIED HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF) WITH REDUCED IMMUNOGENICITY |
摘要 |
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for th e polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CS F proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
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申请公布号 |
CA2439926(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
CA20022439926 |
申请日期 |
2002.02.28 |
申请人 |
MERCK PATENT GMBH |
发明人 |
CARR, FRANCIS J.;CARTER, GRAHAM |
分类号 |
C12N15/09;A61K38/00;A61P7/00;A61P37/04;A61P43/00;C07K14/00;C07K14/535;C12N15/27;(IPC1-7):C12N15/27;C07K7/06;A61K38/08;C07K7/08;A61K38/10;A61K38/18;A61K38/19;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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