发明名称 |
METHODS FOR CLINICAL DIAGNOSIS |
摘要 |
A method for the identification of foetal cell nuclei, chromosomes or DNA in a maternal blood or vaginal sample, said method comprising: a) subjecting chromosomes of cell nuclei in said sample to exonucleolytic digestion by an enzyme so as to remove end regions of each chromosome; and b) detecting the presence of a DNA sequence remaining in foetal DNA but absent from maternal DNA as a result of said digestion process. Once identified, the foetal DNA can be subject to diagnosis for example to detect chromosomal abnormalities. |
申请公布号 |
WO0181626(A3) |
申请公布日期 |
2002.09.12 |
申请号 |
WO2001GB01767 |
申请日期 |
2001.04.20 |
申请人 |
SIMEG LIMITED;HULTEN, MAJ, ANITA |
发明人 |
HULTEN, MAJ, ANITA |
分类号 |
G01N33/53;C12N15/09;C12Q1/34;C12Q1/68;G01N33/566;G01N33/58 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|