发明名称 NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY
摘要 Compounds which can be represented by the general formula (I) and in which A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, -R1 is selected from an alkyl group having fr om 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with t he nitro group or the methyl group, -R2 is selected independently from hydrogen , an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, -R3 and R4 are selected independently from hydrogen and an alkyl gro up having from 1 to 3 carbon atoms, -R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl, and hydroxyl groups, -n is a whole number from 0 to 6, and the amidine groups is in the para or meta position relative to the "-A-NH-" group.
申请公布号 CA2437109(A1) 申请公布日期 2002.09.12
申请号 CA20022437109 申请日期 2002.02.06
申请人 ROTTA RESEARCH LABORATORIUM S.P.A. 发明人 ARTUSI, ROBERTO;ZANZOLA, SIMONA;ROVATI, LUCIO CLAUDIO;MAKOVEC, FRANCESCO
分类号 C07D277/10;A61K31/167;A61K31/17;A61K31/404;A61K31/426;A61K31/4402;A61P1/04;A61P19/02;A61P29/00;A61P35/00;A61P37/02;A61P43/00;C07C257/14;C07C257/22;C07C279/18;C07C279/36;C07C335/20;C07D209/14;C07D209/40;C07D213/36;C07D213/40;C07D277/48;(IPC1-7):C07C279/36;A61K31/155;C07D209/18;C07D209/42 主分类号 C07D277/10
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