发明名称 |
ANTI-INVASIVE AND ANTI-ANGIOGENIC COMPOSITIONS AND METHODS FOR TREATING BRAIN TUMORS AND OTHER DISEASES |
摘要 |
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro . A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivatives, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis . The disclosed compositions and methods are useful for suppressing the growth and metastasis of tumors, including a number of highly malignant brain tumors, and for treating endometriosis and diseases associated with pathogenic neovascularization including various ocular diseases.
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申请公布号 |
WO02069885(A2) |
申请公布日期 |
2002.09.12 |
申请号 |
WO2002US01560 |
申请日期 |
2002.01.22 |
申请人 |
ANGSTROM PHARMACEUTICALS, INC.;MAZAR, ANDREW, P.;JONES, TERENCE, R. |
发明人 |
MAZAR, ANDREW, P.;JONES, TERENCE, R. |
分类号 |
A61K38/00;A61P35/04;C07K7/06;C07K14/47;(IPC1-7):A61K/ |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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