发明名称 |
Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
摘要 |
Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second a time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable gamma of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.
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申请公布号 |
US2002125145(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
US20020144095 |
申请日期 |
2002.05.10 |
申请人 |
OHARA TIMOTHY;KERMANI MAHYAR Z. |
发明人 |
OHARA TIMOTHY;KERMANI MAHYAR Z. |
分类号 |
G01N33/483;A61B5/145;G01N27/26;G01N27/327;G01N27/416;G01N33/487;G01N33/66;G01N33/96;(IPC1-7):G01N27/416 |
主分类号 |
G01N33/483 |
代理机构 |
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代理人 |
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地址 |
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