| 摘要 |
<p>The invention relates to novel glutarimide derivatives of general formula (I) and to their homologs of a dimeric nature I-Q-I, wherein Z can be an imide or a bisimide of various types; e Y and Q can be different types of atoms, chains or groups of organic chemistry. Said derivatives are characterized by their concomitant antiangiogenic activity of solid tumors and their inhibiting action of the alpha tumor necrosis factor TNF-α. Said compounds are prepared by general imide synthesis methods. Various salts, prodrugs of salts and medicaments are obtained for use in anti-cancer coadjuvant therapy using any clinically available means.</p> |
