发明名称 |
PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC |
摘要 |
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease believed to be caused by an inflammatory process in the pancreas leading to selective destruction of the cells. Inducible cyclooxygenase (COX-2) is expressed under inflammatory conditions and its product prostaglandin E2(PGE2) is an important inflammation mediator. Administration of the selective COX-2 inhibitor such as, e.g., NS-398 prevents the onset of diabetes in mice brought on by multiple low-doses of streptozotocin (STZ). Histological observations indicated that STZ-mediated destruction of cells was prevented by NS-398 treatment. Delayed (day 3) administration of NS-398 was also protective in this model. These results demonstrate the critical importance of COX-2 activity in autoimmune destruction of cells, and point to the fact that COX-2 inhibition should provide a preventive therapy against IDDM or other autoimmune problems, including allograft rejection. Inhibitors of NF- B activation may also be used to prevent IDDM and allograft rejection. |
申请公布号 |
WO0185175(A3) |
申请公布日期 |
2002.09.12 |
申请号 |
WO2001US15174 |
申请日期 |
2001.05.10 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
TABATABAIE, TAHEREH;KOTAKE, YASHIGE |
分类号 |
A61K31/00;A61K31/40;A61K31/63;A61P5/48 |
主分类号 |
A61K31/00 |
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