Oestranes - by reducing delto 8(9)-dehydrooestranes with - trifluoroacetic acid and

摘要

Sterically-directed process for oestranes (I): of natural configuration (where R is O, OH, OCOCH3; R1 is CH3, C2H5 or n-C3H7; R2 is H, CH3 or COCH3; n is 1 or 2) by reducing corresp. DELTA 8(9)-dehydro-oestrane with a mixture of trifluoroacetic acid and triethylsilane in inert organic solvent followed by isolation of the product. The process can be used in the synthesis of female sex-hormones: d- and d, l-oestra-3,17 beta diol used in the treatment of sexual disorders, athero sclerosis and tumours. It may also be used in the synthesis of 19-nor-steroids, contraceptive prepns. and anabolics used as growth promotors for economically-important animals.