Verfahren zur Herstellung der Enantiomere der 2-substituierten beta-Aminosäuren

摘要

The invention relates to a method for the production of the enantiomers of 2-substituted beta amino acids, which are important as intermediate products for pharmaceutical research and the pharmaceutical industry. According to the invention, nitroacrylic acid esters having metallorganic compounds are reacted with chiral ligands in aprotic solvents in the presence of catalytic fractions of a copper salt complex at temperatures below 0 DEG C and the resulting addition product is hydrogenated in a manner known per se. The ester is saponified or cleaved and the end product is purified and produced by crystallization. Ligands forming copper complexes and containing phosphorus as atom donors are preferably used. The inventive method makes it possible to produce enantiomers economically and with high yields.