发明名称 |
SILYMARIN FORMULATION COMPOSITION IMPROVED IN BIOAVAILABILITY |
摘要 |
PURPOSE: A novel composition prepared by adding a suitable amount of tromethamine and poloxamer 407 to poorly water soluble silymarin to increase water solubility and improve bioavailability is provided. Therefore, the composition is surprisingly improved in an elution rate and has an LD50 of 9,756mg/kg. CONSTITUTION: This silymarin formulation composition is obtained by mixing tromethamine and poloxamer 407 in a ratio of 1:1, solubilizing in 95% ethanol, and drying under reduced pressure at 40deg.C or less. In the process, 0.01 to 1.0% by weight sodium lauryl sulfate is also added instead of poloxamer 407. The silymarin formulation is a soft gelatin capsule.
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申请公布号 |
KR20020071235(A) |
申请公布日期 |
2002.09.12 |
申请号 |
KR20010011235 |
申请日期 |
2001.03.05 |
申请人 |
BUKWANG PHARMACEUTICAL COMPANY LTD. |
发明人 |
CHOI, DONG YEONG;KOO, CHANG HWI;SONG, IL YONG |
分类号 |
A61K9/48;A61K31/133;A61K31/357;A61K47/10;A61K47/18;A61K47/20;(IPC1-7):A61K31/357 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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