Process for the preparation of 4(R)-hydroxy cyclopent-2-en1(S)-acetate

摘要

The present invention relates to a process for the preparation of 4-(R)-hydroxycyclopent-2-en-1 (S)-acetate of the formula 2by reacting meso-cyclopent-2-en-1, 4-diacetate of formula 1with a whole cell enzyme in a mixture of a buffer and an organic solvent, filtering the reaction mixture to remove the enzyme, extracting the resultant compound with an organic solvent, and removing the solvent to obtain the desired product.