| 摘要 |
The present invention provides a process of preparing a compound of the formula IVwherein:R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl,R3 is H or -(C1-C6)alkyl,R6 is -NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C1-C4)alkyl or and R7 and R8 are each individually hydrogen, -(C1-C6)alkyl, -(CH2)pOH, -(CH2)p-piperidyl, -(CH2)pS(C1-C6)alkyl, -(CH2)pO(C1-C6)alkyl where R9 is (C1-C6)alkyl;P is an integer from 1-3 both inclusive;q is 0 or 1; andt is 1 to 6 both inclusive;or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.
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