| 发明名称 |
Method of inhibiting cell function associated with CCR2 by anti-CCR2 amino-terminal domain antibodies |
| 摘要 |
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
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| 申请公布号 |
US6448021(B1) |
申请公布日期 |
2002.09.10 |
| 申请号 |
US20010905849 |
申请日期 |
2001.07.13 |
| 申请人 |
MILLENIUM PHARMACEUTICALS, INC. |
发明人 |
LAROSA GREGORY J. |
| 分类号 |
G01N33/53;A61K39/395;A61P9/10;A61P29/00;A61P31/18;A61P37/02;A61P43/00;C07K16/00;C07K16/28;C12N5/10;C12N15/02;C12N15/09;C12P21/08;C12Q1/02;C12R1/91;G01N33/566;G01N33/577;(IPC1-7):G01N33/53;C12Q1/70 |
主分类号 |
G01N33/53 |
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