发明名称 |
PHARMACEUTICAL FORMULATIONS CONTAINING THE RENIN-ANGIOTENSIN SYSTEM INHIBITORS AND USE THEREOF IN THE PREVENTION OF STROKE, DIABETES AND/OR CONGESTIVE HEART FAILURE |
摘要 |
Novel use of an inhibitor of the renin-angiotensin system or derivative (I) in the manufacture of a medicament for the prevention of stroke in patients exhibiting normal or low blood pressure, diabetes and/ or congestive heart failure (CHF) with no pre-existing CHF. Independent claims are also included for: a method of preventing of stroke in patients exhibiting normal or low blood pressure, diabetes and/ or congestive heart failure (CHF) with no pre-existing CHF; and a formulation for use in the prevention of stroke in patients exhibiting normal or low blood pressure, diabetes and/ or congestive heart failure (CHF) with no pre-existing CHF. ACTIVITY : Cerebroprotective; Cardiant; Antidiabetic. Treating 9,541 patients who are at risk for cardiovascular events due to a history of previous ischemic heart disease, stroke, peripheral arterial disease or individuals with diabetes with ramipril for 6 years resulted in a 32% reduction in the number of patients who developed a stroke, 21% who developed congestive heart failure, and 36% reduction who developed diabetes. MECHANISM OF ACTION : Angiotensin converting enzyme (ACE) inhibitor; an angiotensin II antagonist. |
申请公布号 |
SK2702002(A3) |
申请公布日期 |
2002.09.10 |
申请号 |
SK20020000270 |
申请日期 |
2000.08.25 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
SCHOELKENS BERNWARD;BENDER NORBERT;RANGOONWALA BADRUDIN;DAGENAIS GILLES;GERSTEIN HERTZEL;LJUNGGREN ANDERS;YUSUF SALIM |
分类号 |
A61K45/00;A61K31/00;A61K31/357;A61K31/401;A61K31/4025;A61K31/403;A61K31/404;A61K31/41;A61K31/4166;A61K31/4178;A61K31/4184;A61K31/435;A61K31/497;A61K31/519;A61K31/55;A61K31/551;A61K31/554;A61P3/10;A61P9/02;A61P9/04;A61P9/10;A61P43/00;C07D209/52 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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