| 摘要 |
PROBLEM TO BE SOLVED: To provide an industrially suitable method of producingβ-ketonitriles in which the high purityβ-ketonitriles are obtained in high yield in a simple manner from a readily available alphatic carboxylic acid esters. SOLUTION: The method of producing aβ-ketonitrile includes (A) a step of reaction/operation processes wherein an alphatic carboxylic ester is reacted with acetonitrile in the presence of a metal alkoxide, synthesizing a metal salt of theβ-ketonitrile, (B) a step of layer separation process wherein the reacted solution is separated into an organic layer and a water layer by adding and mixing the organic solvent and water thereto, obtaining the water layer (solution) containing the metal salt of theβ-ketonitrile, and (C) a step of neutralization/extraction processes wherein the solution containing the metal salt of theβ-ketonitrile obtained by the layer separation is neutralized by addition of an acid and the liberatedβ-ketonitrile is extracted by an organic solvent.
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