发明名称 |
AN IMAGING FLUOROMETER FOR TIME RESOLVED FLUORESCENCE |
摘要 |
The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer. under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput. |
申请公布号 |
WO02068942(A2) |
申请公布日期 |
2002.09.06 |
申请号 |
WO2002IB00590 |
申请日期 |
2002.02.27 |
申请人 |
IMAGING RESEARCH INC.;ZARATE, CARLOS;DONDERS, PAUL;YEKTA, AHMED;MASOUMI, ZAHRA;RAMM, PETER |
发明人 |
ZARATE, CARLOS;DONDERS, PAUL;YEKTA, AHMED;MASOUMI, ZAHRA;RAMM, PETER |
分类号 |
G01N21/64;G01N21/78;G01N33/483 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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