MODIFIED THROMBOPOIETIN WITH REDUCED IMMUNOGENICITY
摘要
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human thrombopoietin (TPO) to result in TPO proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo<i/>.
申请公布号
WO02068469(A2)
申请公布日期
2002.09.06
申请号
WO2002EP01931
申请日期
2002.02.22
申请人
MERCK PATENT GMBH;CARR, FRANCIS, J.;CARTER, GRAHAM