NEGATIVE REGULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR ACTIVITY BY MIG-6

摘要

The present invention relates to the use of a Mig-6 protein or a nucleic acid coding therefor for the manufacture of an agent for the modulation of epidermal growth factor receptor (EGFR) activity. Further, the use of Mig-6 or nucleic acids coding therefor as a target for the modulation of EGFR receptor activity is disclosed. The invention also relates to a method for identifying novel substances capable of modulating EGFR activity. The modulation of EGFR activity preferably comprises an inhibition of the EGFR signal and is thus suitable for applications, particularly diagnostic or medical applications, wherein an inhibition of EGFR activity is desired. Thus, the present invention relates to novel methods for diagnosing, treating or preventing EGFR overexpression associated disorders such as tumors.