| 摘要 |
The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order : A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
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| 申请人 |
NOVARTIS AG |
发明人 |
ENNIST, DAVID LEONARD;POLICE, SESHIDHAR REDDY;CHENG, CHENG;JAKUBCZAK, JOHN LEONARD;CONNELLY, SHEILA;FORRY-SCHAUDIES, SUZANNE;PHIPPS, SANDRINA;CLARKE, LORI;STEWART, DAVID A.;HAY, CARL M.;XIE, YUEFENG;KALEKO, MICHAEL;RYAN, PATRICIA CLARA;HALLENBECK, PAUL L.;GORZIGLIA, MARIO |
