发明名称 |
DETERMINING CARTILAGE DEGENERATION AND AGING USING BONE MORPHOGENIC PROTEINS |
摘要 |
Methods are provided for determining cartilage degeneration or regeneration in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP- 1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determini ng a predisposition for, or monitoring joint tissue degeneration and regenerati on in a patient including inflammatory joint disease or age-related disorders.< /SDOAB>
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申请公布号 |
CA2438757(A1) |
申请公布日期 |
2002.09.06 |
申请号 |
CA20022438757 |
申请日期 |
2002.02.20 |
申请人 |
STRYKER CORPORATION |
发明人 |
RUEGER, DAVID C.;CHUBINSKAYA, SUSANNA;KUETTNER, KLAUS E. |
分类号 |
G01N33/53;C12Q1/68;G01N33/50;G01N33/543;G01N33/564;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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