| 发明名称 |
PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS |
| 摘要 |
Phenylalanine enamide derivatives of formula (1) are described: wherein R1, RX, RY, RZ, X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells. |
| 申请公布号 |
CA2434666(A1) |
申请公布日期 |
2002.09.06 |
| 申请号 |
CA20022434666 |
申请日期 |
2002.01.18 |
| 申请人 |
CELLTECH R&D LIMITED |
发明人 |
HEAD, JOHN CLIFFORD;PORTER, JOHN ROBERT;JOHNSON, JAMES ANDREW;BROWN, JULIEN ALISTAIR;BAILEY, STUART;BRAND, STEPHEN |
| 分类号 |
A61K31/198;A61K31/4375;A61K31/44;A61K31/4406;A61K31/497;A61P3/10;A61P9/00;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P37/00;A61P37/06;A61P43/00;C07C229/34;C07C229/46;C07C233/82;C07C321/22;C07C323/30;C07D213/81;C07D213/89;C07D401/12;C07D405/12;C07D409/12;C07D413/12;C07D471/04;(IPC1-7):C07D213/81;C07C229/36 |
主分类号 |
A61K31/198 |
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