发明名称 |
INJECTABLE WATER-IN-OIL EMULSIONS |
摘要 |
The present invention provides adjuvants, for use in vaccine formulation, comprising a water-in-oil emulsion, characterised in that said emulsion comprises a polymeric emulsifier which is a block copolymer having a general formula A-COO-B-OOC-A, in which B is the divalent residue of a water-soluble polyalkylene glycol and A is the residue of a oil-soluble complex monocarboxylic acid. Such polymeric emulsifier, as well as the preparation thereof, has been disclosed in GB 2002400 and WO9607689. Preferably in the blockcopolymers of formula A-COO-B-OOC-A, component B is derived from polyethylene glycol and components A are derived from polyhydroxystearic acid, preferably from poly(12-hydroxy-stearic acid). Most preferred emulsifiers used in the adjuvants according to the invention are Arlacel P135, a PEG 30 Dipolyhydroxystearate. Another, similar, emulsifier for use with the invention is ATLOX®4912. Both Arlacel P135 and ATLOX®4912 are block copolymers (A-B-A) of polyethylene glycol and hydroxystearic acid with a molweight of approximately 5000 commercially available from ICI. It has een found that with the use of these emulsifiers adjuvants based on w/o emulsions that are stable and have a low viscosity can be obtained that may be based on metabolisable oils. Said adjuvants have an excellent adjuvant activity, and are well tolerated.
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申请公布号 |
WO02067899(A1) |
申请公布日期 |
2002.09.06 |
申请号 |
WO2002EP02145 |
申请日期 |
2002.02.26 |
申请人 |
AKZO NOBEL N.V.;JANSEN, THEODORUS;SCHIJNS, VIRGIL, ELISABETH, JOSEPH, CASPAR;HERMKENS, ERIK |
发明人 |
JANSEN, THEODORUS;SCHIJNS, VIRGIL, ELISABETH, JOSEPH, CASPAR;HERMKENS, ERIK |
分类号 |
A61K9/10;A61K9/00;A61K9/107;A61K39/00;A61K39/39;A61K47/14;A61K47/34;A61K47/44;B01F17/34;(IPC1-7):A61K9/107 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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