ACTIVATION OF LYMPHOCYTE POPULATIONS EXPRESSING NKG2D USING ANTI-NKG2D ANTIBODIES AND LIGAND DERIVATIVES

摘要

The present invention provides various methods for stimulating a cell expressing an NKG2D receptor, including artificially engineered cell populations. Provided, in accordance with the invention, are monoclonal antibodies that bind to NKG2D extracellular domains and facilitate the interaction of other NKG2D domains with DAP10. Of particular interest are treating cancers and viral infections, and the stimulation, both in vivo and ex vivo, of cytokine secretion.