发明名称 |
RESTORE CANCER-SUPPRESSING FUNCTIONS TO NEOPLASTIC CELLS THROUGH DNA HYPOMETHYLATION |
摘要 |
Compositions and methods are provided for treating diseases associated with abnormal cell proliferation such as cancer by storing inherent tumor-suppressing functions of neoplastic cells through DNA hypomethylation. The method comprises: delivering to a patient suffering from cancer a therapeutically effective amount of a DNA mehtylation inhibitor such as decitabine, in combination with an effective amount of an anti-neoplastic agent whose activity as an anti-neoplastic agent in vivo is adversely affected by aberrant DNA methylation. The anti-neoplastic agent can be an alkylating agent, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon. |
申请公布号 |
WO02067681(A1) |
申请公布日期 |
2002.09.06 |
申请号 |
WO2002US04135 |
申请日期 |
2002.02.11 |
申请人 |
SUPERGEN, INC.;RUBINFELD, JOSEPH;CHANG, LUCY;DIMARTINO, JORGE |
发明人 |
RUBINFELD, JOSEPH;CHANG, LUCY;DIMARTINO, JORGE |
分类号 |
A61K45/06;A61K31/00;A61K31/07;A61K31/138;A61K31/203;A61K31/282;A61K31/495;A61K31/57;A61K31/706;A61K33/24;A61K39/395;A61P35/00;A61P43/00 |
主分类号 |
A61K45/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|