(2-HYDROXY)ETHYL-THIOUREAS USEFUL AS MODULATORS OF ALPHA2B ADRENERGIC RECEPTORS

摘要

Compounds of formula (i) and of formula (ii), wherein the symbols have the meaning disclosed in the claims, specifically or selectively modulate alpha 2A adrenergic receptors and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardiovascular and/or sedatory activity. The invention also relates to a method of activating alpha 2B or alpha 2C adrenergic receptors in a mammal by administering a compound that has alpha 2Bor alpha 2C adrenergic receptor activity and has no significant alpha 2A agonist activity.