CYTOTOXIC T-LYMPHOCYTE ANTIGEN-4 OR INTERLEUKIN-10 POLYMORPHISMS AS PREDICTORS OF RESPONSE TO THERAPEUTIC INTERVENTION
摘要
A composition and process are provided for predicting the responsiveness of an individual to therapy for a pathological condition is based on detecting nucleic acid allele sequences in an interleukin-10 regulatory region or cytotoxic t-lymphocyte antigen-4 promoter or exon region of the individual. The detected nucleic acid allele is then associated with the level of therapeutic responsiveness to a pathological condition based upon genotype. Comparison across multiple alleles and regions improves the predictive nature of the process.
申请公布号
WO02068699(A1)
申请公布日期
2002.09.06
申请号
WO2002US06207
申请日期
2002.02.27
申请人
UAB RESEARCH FOUNDATION;YEE, LELAND;TANG, JIANMING;KASLOW, RICHARD, A.;VAN LEEUWEN, DIRK J.
发明人
YEE, LELAND;TANG, JIANMING;KASLOW, RICHARD, A.;VAN LEEUWEN, DIRK J.