发明名称 Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents
摘要 <p>The new compsns. contain trans nitro cpds. of formula (I): (where R is H or lower alkyl; R1 is 5- or 6-membered carbocycle or heterocycle linked through a C atom to the ethylene gp. and which may be substd. by one or more of amine, mono or di-alkylamine, nitro, halogen, alkyl, aralkyl, alkoxy, aralkoxy, hydroxy or methylenedioxy, or it may contain a carbon chain making with R1 an aromatic polycyclic system). Specific cpds. include trans beta-nitro 4-fluoro and 3,4,5-trimethoxy styrene, trans 2-nitro-1-(alpha-naphthyl)ethylene, trans 2-nitro-2-methyl-1-(beta-naphthyl)ethylene, trans beta-nitro 4-allyloxy 4-propoxy, 3-methyl-4-isopropyl and 2,6-dinitro-3-methyl-4-isopropyl styrenes.</p>
申请公布号 FR2115089(A1) 申请公布日期 1972.07.07
申请号 FR19700042945 申请日期 1970.11.30
申请人 ANVAR 发明人
分类号 C07C205/03;C07C205/04;C07C205/06;C07C205/09;C07C205/16;C07C205/19;C07C205/31;C07C205/32;C07C205/44;C07C205/54;C07D333/12;(IPC1-7):61K27/00;07C79/00;07D/ 主分类号 C07C205/03
代理机构 代理人
主权项
地址