发明名称 |
Epoxy steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure |
摘要 |
A combination therapy comprising a therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of a beta-adrenergic antagonist is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred beta-adrenergic antagonists are those compounds having high potency and bioavailability. Preferred epoxy-steroidal aldosterone receptor antagonists are 20-spiroxane steroidal compounds characterized by the presence of a 9alpha,11alpha-substituted epoxy moiety. A preferred combination therapy includes the beta-adrenergic antagonist metoprolol ((±)1-(isopropylamino)-3-[p-(2-methoxyethyl)phenoxyl]-2-propanolol succinate) and the aldosterone receptor antagonist epoxymexrenone.
|
申请公布号 |
US2002123485(A1) |
申请公布日期 |
2002.09.05 |
申请号 |
US20010917403 |
申请日期 |
2001.07.27 |
申请人 |
ALEXANDER JOHN C.;SCHUH JOSEPH R. |
发明人 |
ALEXANDER JOHN C.;SCHUH JOSEPH R. |
分类号 |
A61K31/138;A61K31/166;A61K31/167;A61K31/18;A61K31/216;A61K31/403;A61K31/58;A61K31/585;A61K45/06;A61P9/00;A61P9/12;A61P43/00;C07D209/86;C07J21/00;C07J71/00;(IPC1-7):A61K31/58;A61K31/405;A61K31/137 |
主分类号 |
A61K31/138 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|